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THE EFFECT OF THE PREPARATION DZHEREL0-I ON THE IMMUNITY AND ANTIINFECTIVE RESISTANCE

Lisyaniy N.I.1, Pilipchuk V.C.1, Betekay L.N.1, Lisyanaya T.A.2, Ponomaryova I,G.2

THE EFFECT OF THE PREPARATION DZHEREL0-I  ON THE IMMUNITY AND ANTIINFECTIVE RESISTANCE

1.The state Institution Romodanov Neurosurgery Institute. National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine;

2.The State Institution PAG Institute, National Academy of Medical Sciences of Ukraine, Kyiv Ukraine.

Various groups of immunomodulating drugs have been widely used in the modem clinical immunology, namely, glucocorticoids, monoclonal antibodies, interferons, adjuvants. At the same time, there is a limited list of drugs that have a mild therapeutic and preventive effect on the immune system. The purpose of our research was to study the effect of the complex herbal preparation Dzherelo-I on the local immune system and microbiocenosis of the oral cavity, namely, on microbial and viral contamination of the oral fluid. The drug Dzherelo-I is a complex alcohol-water extract of 12 plants with immunomodulating and antioxidant properties. The drug is applied in the form of drops for 14-16 days (according to the instructions) and is recommended for healthy people. Investigation of immunological, microbiological and virological parameters of the oral fluid was carried out before the beginning of the drug and on 2,16,45 days after the end of the course. It was established a 3-4-fold increase in the level of a-interferon in saliva immediately after the end of the drug administration, the level of slgA increased during the period from 15 to 45 days, that indicates activation of local adaptive immunity. The total microbial number in the oral fluid was decreased from Ig 8.4 cfu/ml to Ig 5.4 cfu/ml on day 30 of the drug administration. The number of fungi, gram-negative pathogens, hemolytic staphylococci was significantly lower than that before the drug administration. Leukocyte fraction and the number of epithelial cells with adhesive microbial associations was also decreased in oral fluid. The detection of herpes viruses (HV) in the oral fluid by PCR method revealed only HV 4,6 and 7 in 86-90% of cases. HV 1,2 and CMV viruses were not delected In the early period after the application of the drug Dzherelo-I there was a decrease in the DNA level of HV4 and 6. The content of DNA of HV7 was reduced only on the day 45 of observation period. Our results confirm the immunomodulating and anti-infective characteristics of the Dzherelo-I, and allow to recommend it as curative and preventive drug to activate local immunity and to increase resistance to infectious agents.

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