рус     /     укр     /     eng

Джерело-ПІ

Джерело-ПІ всі продукти »
КОНСУЛЬТАЦІЙНО-ДІАГНОСТИЧНІ ЦЕНТРИ (прийом лікаря - безкоштовний!):
Київ, бульвар Кольцова, 14-Е
тел: (044) 585-41-07
показати на карті

Київ, проспект Правди, 80-А
тел. (044) 463-06-30
показати на карті  

Київ, вулиця Хорива, 4
тел: (044) 467-67-25

Режим роботи центрів:
пн-пт: 10:00-19:00
сб: 10:00-18:00
нд: - вихідний

Бухгалтерія:
тел.  (044) 463-50-76
факс (044) 463-06-31

Відділ продажу та маркетингу:
тел. +38 (044) 463-50-77 

 

Effect of Immunomodulator Dzherelo In HIV/TB co-Infected patients receiving anti-tuberculosis therapy under DOTS

 

Lyudmila G. Nikolaeva1 *, Tatyana V. Maystat1, Volodymyr S. Pylypchuk2, Yuri L. Volyanskii3, Lllla A Masyuk4. Galyna Kutavna5*. 1 Kharkov Regional AIDS Prophylaxis and Prevention Center, Kharkov Medical Academy of Postgraduate Education, 6 Bor'by street, Kharkov 61044, Ukraine; 2Ekomed LLC. Prospect Pravdy 80-A, Kiev 04208, Ukraine: 3I.I. Mechnlkov inslltute of Microbiology and Immunology, Kharkov 61057, Ukraine; 'Jovtnevsky Correctional Colony No.17, State Department of the Penitentiary of Ukraine In Kharkov Region, Kharkov, Ukraine; 5Luhansk Regional AIDS Center and Luhansk State Medical University, Luhansk 91045, Ukraine; "Corresponding author: E-mail: kutsyna@list.ru
Open-label, phase II clinical trial was conducted in 40 HIV/TB dually infected patients to evaluate the effect of oral Immunomodulator Dzherelo on immune and viral parameters. The anti-retrovlral therapy naive patients were randomized into two equal groups, to be given anti-tuberculosis therapy (ATT) under DOTS. The arm A, which served as a conlrol, received Isonlazid (H); Rimfapicin (R); Pyrazinamide (Z); Streptomycin (S); and Ethambutol (E), and arm B received 50 drops of Dzherelo twice per day in addition to HR2SE. After 2 months the total CD3 lymphocytes increased from 728 to 921 cells/ul (P=0.025) in Dzherelorecipients, whereas in the control they decreased from 651 to 585 cells (P=0.25). The population of CD4 T-cells expanded in Dzherelo arm (174 to 283; P=0.00003) but declined In ATT group (182 to 174; P=0.34). The CD8 cells fluctuated slightly upward In both groups: 159>180 (P=0.17) and 159>183 (P=0.13).The ratio between CD4/CD8 cells deteriorated In arm A (1.213>0.943; P=0.002) but improved in arm B (1.244>1.536; P=0.007). The percent of CD3+HLA-QH+ activated lymphocytes fell in ATT (22.6>20.S; P=0.004), but rose in Dzherelo recipients (21.5>30.5; P=0.0001).The changes in CD20 B lymphocytes were Insignificant In both arms (28.4%>28.6%; P=0.4) and (27.2%>26.7%; P=0.38). No differences were seen in the amount of CD3-CD16+CD56+ natural killer (NK) cells In arm A (21.3%>22.6%; P=0.1), while in Dzherelo recipients they declined (19.9%>14.5%; P=0.003).The average viral load, as measured by plasma RMA-PCR, decreased in Dzherelo group (2,174>1,558 copies/ml; P=0.002), but increased In ATT group (1,907>2,076; P=0.03). Dzherelo has a favorable effect on the Immune status and viral burden in HIV/TB patients when given as an Immunomodulating adjunct to ATT.

 

 

Читайте також:

Treatment of cavitary and infiltrating pulmonary tuberculosis with and without the immunomodulator DzhereloClinical validation of sublingual formulations of Immunoxel (Dzherelo) as an adjuvant immunotherapy in treatment of TB patientsImmune approaches in tuberculosis therapy: a brief overviewAdjuvant Immunotherapy of Extensively Drug-Resistant Tuberculosis (XDR-TB) in Ukraine
Rated by PING
© 2010 - Екомед. Всі права захищені.
Розробка сайтів
Подбайте про своє здоров'я разом з порталом Спортивні клуби України